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Review. The Hubrecht Institute strongly supports open access of all scientific publications. 5,898. 2020 – present  Member of the Board of Genentech, South San Francisco 2018 – present  Scientific advisor Life Science Partners, Amsterdam and Clevers, H. Visualization of the short-range Wnt gradient in the intestinal stem cell niche. 17 Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, 3584 CG Utrecht, the Netherlands. These organoids recapitulate many aspects of their tissue of origin and allow the study of a multitude of physiological and pathological processes. The scientific advisory board of the Hubrecht Institute meets once a year and is involved in the tenure track evaluations of the junior PI’s. The organoid-based swelling assay has meanwhile become clinical practice in the Netherlands to identify and treat patient with rare mutations that respond to the Vertex drugs (“Cystic Fibrosis Patients benefit from Mini Guts”. View ORCID Profile Hans Clevers, View ORCID Profile Alexander van Oudenaarden * Oncode Institute, Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, 3584 CT Utrecht, Netherlands. Hubrecht Organoid Technology (HUB) was founded by the Hubrecht Institute, the University Medical Center Utrecht, and the Royal Netherlands Academy of Arts and Sciences (KNAW). Hubrecht Institute: promotional video. Uppsalalaan 8 Dr. Clevers received his M.D. Cell 136: 903-912 (2009), 27)           Sato, T., Vries, R., Snippert, H., van de Wetering, M., Barker, N., Stange, D., van Es, J., Abo, A., Kujala, P., Peters, P., and Clevers, H. Single lgr5 gut stem cells build crypt-villus structures in vitro without a stromal niche. This research leads to innovation in treatment of cancer, diabetes and cardiovascular diseases among others. Therefore, we provide PDF files of all publications on our website for personal use. Gijs van den Brink. ↵ † Present address: … Prof. Dr. Alfonso Martinez Arias, University of Cambridge, Cambridge The Wnt target gene encoding the transcription factor Achaete scute-like 2 controls the fate of the intestinal stem cell (26). 2017 – 2018      President of the International Society for Stem Cell Research (ISSCR) Forskolin opens the CFTR channel, resulting in rapid swelling of normal organoids. A living biobank of breast cancer organoids captures disease heterogeneity. At the start of their PhD, the PhD students draft a Training & Supervision Agreement (TSA) and during their PhD they have yearly meetings with their supervisory committee, which includes 2-3 independent researchers. and Clevers, H. de Lau, W., Barker, N., … and Clevers, H. Li, V.S., Ng, S.S., Boersema, P.J., Low, T.Y., Karthaus, W.R., Gerlach, J.P., Mohammed, S., Heck, A.J., Maurice, M.M., Mahmoudi, T. and Clevers, H. Snippert, .J., van der Flier, L.G., Sato, T., van Es, J.H., van den Born, M., Kroon-Veenboer, C., Barker, N.,Klein, A.M., van Rheenen, J. Benjamin D. Simons, B.D. The Hubrecht Institute is a research institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), situated on the Utrecht Science Park. This allowed the institute to grow into an internationally renowned research institute and facilitated the link with (pre)clinical research. Wnt signaling intimately interacts with the BMP and Notch cascades to drive proliferation and inhibit differentiation in intestinal crypts and adenomas (17, 20). Researchers from the UMC Utrecht work alongside researchers from the Hubrecht Institute in this new building. Nature 507: 362-365 (2014), 45)           Karthaus, W.R., Iaquinta, P.J., Drost, J., Gracanin, A., van Boxtel, R., Wongvipat, J., Dowling, C.M., Gao, D., Begthel, H., Sachs, N., Vries, R.G., Cuppen, E., Chen, Y., Sawyers, C.L., Clevers, H.C. Research groups. He also serves as Director of the Princess Maxima Center for Pediatric Oncology. Nature 395: 608-612 (1998), 10)           Roose, J., Huls, G., van Beest, M., Moerer, P., van der Horn, K., Goldschmeding, R., Logtenberg, T., and Clevers, H. Synergie between tumor suppressor APC and the beta-catenin/Tcf4 target gene Tcf1. In the UMC Utrecht, research is concentrated in six programs with each a limited number of disease targets. M., Li, V.S., Jose, A., Hatzis, P., Mokry, M., Haegebarth, A., van den Born, M., Chambon, P., Voshol, P., Dor, Y., Cuppenm E., Fillat, C., Clevers, H. van Es, J.H., Sato, T., van de Wetering, M., Lyubimova, A., Yee Nee, A.N., Gregorieff, A., Sasaki, N., Zeinstra, L., van de Born, M., Korving, J., Martens, A.C., Barker, N., van Oudenaarden, A., Clevers, H. Schepers, A.G., Snippert, H.J., Stange, D.E., van den Born, M., van Es, J.H., van de Wetering, M., Clevers, H. Koo, B-K., Spit, M. Jordens, I., Low, T.Y., Stange, D.E., van de Wetering, M., van Es, J.H., Mohammed, S., Heck, A.J.R., Maurice, M.M. 2017 – present  Shaw Prize, Hong Kong Cell 155: 357-368 (2013), 43)           Schwank, G., Koo, B.K., Sasselli, V., Dekkers, J.F., Heo, I., Demircan, T., Sasaki, N., Boymans, S., Cuppen, E., van der Ent, C.K., Nieuwenhuis, E.E., Beekman, J.M., Clevers, H. Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients. As a patient-centered organization, its 11,000 employees are dedicated to prevent disease, improve healthcare, develop new treatment methods and refine existing ones, with quality and patient safety as cornerstones. ↵ * Corresponding author. Verbeek, J.S., Ison, D., Hofhuis, F., Robanus-Maandag, E., te Riele, H., van de Wetering, M., Oosterwegel, M., Wilson, A., MacDonald, H.R. Research at the Hubrecht Institute focuses on developmental biology and stem cells at the organismal, cellular, and molecular level. 2005    Katharine Berkan Judd Award, New York Title. In 2007 the name was changed from Hubrecht Laboratory to Hubrecht Institute. About Us. And Clevers, H. Schilham, M., Oosterwegel, M., Moerer, P., Jing Ya, de Boer, P., van de Wetering, M., Verbeek, S., S., Lamers, W., Kruisbeek, A., Cumano, A., and Clevers, H . 53)           Sachs N, de Ligt J, Kopper O, Gogola E, Bounova G, Weeber F, Balgobind AV, Wind K, Gracanin A, Begthel H, Korving J, van Boxtel R, Duarte AA, Lelieveld D, van Hoeck A, Ernst RF, Blokzijl F, Nijman IJ, Hoogstraat M, van de Ven M, Egan DA, Zinzalla V, Moll J, Boj SF, Voest EE, Wessels L, van Diest PJ, Rottenberg S, Vries RGJ, Cuppen E, Clevers H. A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity. of Immunology, Faculty of Medicine, 2002 – 2012      Director Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, 2002 – 2020      Professor in Molecular Genetics at University Medical Center Utrecht, 2002 – present  Principal Investigator of a research group of ~40 scientists at Hubrecht Institute, Utrecht, 2012 – 2015      President of the Royal Netherlands Academy of Sciences (KNAW), Amsterdam, 2014 – 2020      Chief Scientific Officer of HUB Organoids Technology, Utrecht, 2015 – 2019      Chief Scientific Officer/Director Research of the Princess Máxima Center, Utrecht, 2015 – present  Principal Investigator at the Princess Máxima Center, Utrecht, 2000    Catharijne prize for medical research, 2001    Award from the European Society for Clinical Investigation, 2001    Spinoza Award of the Netherlands Research Council (NWO), 2004    Louis-Jeantet Prize for Medicine, Geneva, Switzerland, 2005    The Science and Society Prize, Amsterdam, 2005    The French honor of “Chevalier de la Legion d’Honneur”, 2005    Katharine Berkan Judd Award, New York, 2006    Rabbi Shai Shacknai Memorial Prize for Immunology and Cancer Research, Jerusalem, 2008    Josephine Nefkens Prize for Cancer Research (Erasmus MC, Rotterdam), 2008    Meyenburg Cancer Research Award, Germany, 2009    The Queen Wilhelmina Dutch Cancer Society Award, Amsterdam, 2010    The United European Gastroenterology Federation (UEGF) Research Prize, 2011    The Ernst Jung Medical Award, Germany, 2012    Association pour la Recherche sur le Cancer (ARC) Léopold Griffuel Prize, Paris, 2012    William Beaumont prize of the American Gastroenterology Association, 2012    Knight in the Order of the Netherlands’ Lion, 2013    The Breakthrough Prize in Life Sciences, 2013    International Dream Team (with Hans Bos) by Dutch Cancer Society (KWF), 2014    Massachusetts General Hospital Award in Cancer Research, 2014    TEFAF Oncology Chair 2014, Maastricht, 2014    Struyvenberg European Society for Clinical Investigation (ESCI) medal, 2015    ISSCR-McEwen Award for Innovation, 2016    The Academy Professor Prize of the Royal Netherlands Academy, 2016    Kazemi Award for Research Excellence in Bio-Medicine, 2016    The Körber European Science Prize, Germany, 2016    The Ilse & Helmut Wachter award, Hamburg, Germany, 2017    Princess Takamatsu Award of Merit, Tokyo, 2018    Großes Verdienstkreuz mit Stern, Germany, 2018    Academia Europaea Erasmus Medal, Barcelona, Spain, 2019    Citation Laureate, Web of Science Group, 2008 – 2015      Louis Jeantet Prize, Geneva, 2013 – 2015      Canada Gairdner Award, Toronto, 2014 – present  Breakthrough Prize in Life Sciences, San Francisco, 2015                     Pezcoller Foundation – AACR International Award for Cancer Research, Italy, 2015                     Dr. Paul Janssen Award, Bruxelles, 2017 – present  Francqui Prize, Bruxelles, 2017                     Kovalenko Medal, National Academy of Sciences Washington, 2002 – present  Central South University, Chang Sha, China, 2014 – 2015      TEFAF Oncology Chair, Maastricht, 2015 – 2016      Visiting professor, Weizmann Institute, Rehovoth, Israel, 2016 – present  Distinguished Visiting Professor, University of Hong Kong, 2015 – present  Visiting professor, University of Melbourne, Australia, 2019 – present  Honorary Director, Fudan Organoid Center, Fudan University, Shanghai, 2019 – present  Foreign Advisory Board Member of Consortium for Neogenetic Medicine, Tokyo, 1999               Member European Molecular Biology Organisation (EMBO), 2000               Member of the Royal Netherlands Academy of Sciences (KNAW), 2009               Member of the Academia Europaea, 2012               Member of the American Academy of Arts and Sciences, 2012               Member of the Royal Netherlands Society of Sciences and Humanities, 2014               Member of the National Academy of Sciences of the USA, 2016               Member of the Academie des Sciences de I’Institut de France, 2017               Member of the Orden Pour le Mérite für Wissenschaften und Künste, Germany, 2019               Foreign Member of the Royal Society, London, United Kingdom, 2019               Honorary Fellow of the Royal Society of Edinburgh, Scotland, 2005 – 2015      Member Scientific Advisory Board of Swiss Institute for Experimental Cancer Research, Lausanne, 2006 – 2008      President of the International Society of Differentiation (ISD), 2007 – 2010      Member of the National Scientific Advisory Board NKI-AVL, Amsterdam, 2012 – 2015      Member of the Board of the American Association of Cancer Research, 2015 – present  Member of the Scientific Advisory Board of the Institute of Molecular Pathology, Vienna, 2016 – 2020      Member of the Scientific Advisory Board of Kallyope, New York, 2016 – present  Member of the Scientific Advisory Board of the Francis Crick Institute, London, 2016 – present  Member of the Scientific Advisory Board of Decibel Therapeutics, Boston, 2016 – present  Member of the Scientific Advisory Board of Surrozen, San Francisco, 2017 – 2018      President of the International Society for Stem Cell Research (ISSCR), 2018 – present  Member of the Scientific Advisory Board of Merus, Utrecht, 2018 – present  Scientific advisor Life Science Partners, Amsterdam, 2019 – present  Non-executive member of the Board of Directors of Roche Holding Ltd, Basel, 2020 – present  Member of the Board of Directors of Genentech, South San Francisco, 2020 – present  Member of the Board of Genentech, South San Francisco, 2020 – present  Member of the Scientific Advisory Board of Volestra Therapeutic Inc., New York, 2020 – present  Chair of the Scientific Advisory Board DImed Inc., Shanghai, 2020 – present  Chair of the Scientific Advisory Board of Xilis, at Duke University (NC), SARS-CoV-2 productively Infects Human Gut Enterocytes, Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli, An organoid platform for ovarian cancer captures intra- and inter-patient heterogeneity, Tubuloids derived from human adult kidney and urine for personalized disease modeling, Identification of enteroendocrine regulators by real-time single-cell differentiation mapping, Long-term expansion of functional mouse and human hepatocytes as 3D organoids, Intra-tumour diversification in colorectal cancer at the single-cell level. M., van den Born, M., Begthel, H., Vries, R.G., Stange, D.E., Toftgård, R., Clevers, H. Sato, T., Vries, R., Snippert, H., van de Wetering, M., Barker, N., Stange, D., van Es, J., Abo, A., Kujala, P., Peters, P., and Clevers, H. van der Flier, L.G., van Gijn, M.E., .., and Clevers, H. Barker N., Ridgway R.A., van Es J.H.,van de Wetering M., Begthel H., van den Born M., Danenberg E., Clarke A.R., Sansom O.J., Clevers, H. Jaks V., Barker N., Kasper M., van Es J.H., Snippert H.J., Clevers H., Toftgård, R. Barker, N, van Es, J.H., Kuipers, J., Kujala P., van den Born, M., Cozijnsen, M., Korving, J., Begthel, H., Peters, P.C., and Clevers, H. Batlle E., Bacani J., Begthel H., Jonkheer S., Gregorieff A., Van de Born M., Malats N., Sancho E., Boon E., Pawson T., Gallinger S., Pals S., Clevers, H. Van Es J.H., Van Gijn M.E., Riccio O., Van den Born M., Vooijs M., Begthel H., Cozijnsen M., Robine S., Winton D.J., Radtke F., Clevers, H. Haramis A.P., Begthel H., van den Born M., van Es J., Jonkheer S., Offerhaus G.J., Clevers H. Baas A.F., Kuipers J., van der Wel N.N., Batlle E., Koerten H.K., Peters P.J., Clevers H.C. Hurlstone A.F., Haramis A.P., Wienholds E., Begthel H., Korving J., Van Eeden F., Cuppen E., Zivkovic D., Plasterk R.H., Clevers H. Battle, E., Henderson, J.T., Beghtel, H., van den Born, M., Sancho, E., Huls, G., Meeldijk, J., Robertson, J., van de Wetering, M., Pawson, T., Clevers, H. Van de Wetering, M., Sancho, E., Verweij, C., de Lau, W., Oving, I., Hurlstone, A., Van der Horn, K., Batlle, E., Coudreuse, D., Haramis, A-P., Tjon-Pon-Fong, M., Moerer, P., Van den Born, M., Soete, G., Pals, S., Eilers, M., Medema, R., Clevers, H. Korswagen, R., Herman, M. and Clevers, H. Roose, J., Huls, G., van Beest, M., Moerer, P., van der Horn, K., Goldschmeding, R., Logtenberg, T., and Clevers, H. Roose, J., Molenaar, M., Peterson, J., Hurenkamp, J., Brantjes, H., Moerer, P., van de Wetering, M., Destree, O., and Clevers, H. Korinek, V., Barker, N., Moerer, P., van Donselaar, E., Huls, G., Peters, P.J. During the last five years, the Hubrecht Institute has been very successful in attracting young talented group leaders who started a tenure track at our institute. 2016    The Academy Professor Prize of the Royal Netherlands Academy Cell 154: 274-284 (2013), 42)           Stange, D.E., Koo, B.K., Huch, M., Sibbel, G., Basak, O., Lyubimova, A., Kujalla, P., Bartfeld, S., Koster, J., Geahlen, J.H., Peters, P.J., van Es, J., van de Wetering, M., Mills, J.C., Clevers, H. Differentiated Troy+ chief cells act as ‘reserve’ stem cells to generate all lineages of the stomach epithelium. The Institute is very strong in developing new methods and transferring this knowledge to institutes and universities in the Netherlands and beyond. This is reflected by our broad introduction program, yearly evaluation meetings and regular drinks and outings to improve integration, collaboration and relaxation. 10 Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. The related Lgr6 marks multipotent skin stem cells (29). In the absence of Wnt signaling, we found that Tcf factors associate with proteins of the Groucho family of transcriptional repressors to repress target gene transcription (9). It promotes quality in science and scholarship and strives to ensure that Dutch scholars and scientists contribute to cultural, social and economic progress. Researchers from the group of Hans Clevers at the Hubrecht Institute have developed a new genetic tool to label specific genes in human organoids, or … A variety of biological processes are being studied, mainly concerning embryonic development and development and homeostasis of organs. h.clevers@hubrecht.eu. During his life Hubrecht assembled a vast amount of embryonic material from a number of species, particularly from the former Dutch colonies of the East Indies. The board of directors, consisting of Prof. Alexander van Oudenaarden (director) and Prof. Jeroen den Hertog (managing director) maintains a flat organizational structure with tenure track positions for junior group leaders. H Clevers. In addition to a highly interactive and international scientific environment, excellent research facilities are available on-site. For these studies, we designed the widely used pTOPFLASH Wnt reporters. About. Life Sciences and Health is one of the main themes of research and education. Electronic address: h.clevers@hubrecht.eu. 10 Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer. Science 285: 1923-1926 (1999), 11)           Korswagen, R., Herman, M. and Clevers, H. Separate beta-catenins mediate Wnt signaling and cadherin adhesion in C. elegans. Utrecht Life Sciences is a platform that supports collaboration and innovation. 32)           Snippert, J., van der Flier, L.G., Sato, T., van Es, J.H., van den Born, M., Kroon-Veenboer, C., Barker, N.,Klein, A.M., van Rheenen, J. Benjamin D. Simons, B.D. 2001    Award from the European Society for Clinical Investigation The Dutch Cancer Society (KWF), the ministries of Economic Affairs and Climate Policy (EZK), Education, Culture and Science (OCW) and Health, Welfare and Sports (VWS), Health~Holland, NWO and ZonMw invest 120 million euros in Oncode Institute. 3584 CT Utrecht 54)           Roerink S.F., Sasaki N., Lee-Six H., Young M.D., Alexandrov L.B., Behjati S., Mitchell T.J., Grossmann S., Lightfoot H., Egan D.A., Pronk A., Smakman N., van Gorp J., Anderson E., Gamble S.J., Alder C., van de Wetering M., Campbell P.J., Stratton M.R., Clevers H. Intra-tumour diversification in colorectal cancer at the single-cell level. Feel safe and work E3 ligases that downregulate Wnt receptors for Pediatric,... In vivo imaging ( 43 ) Molecular mechanisms of tissue development and homeostasis of organs Boston. Vibrant and exciting place to study the origin of mutational signatures in cancer 's hospital,,! Biology 14: 1099-1104 ( 2012 ), 38 ) Boj, s, F., Es! A negative feedback loop to control the size of the future as Institute Director head. Expanded into mini-guts and shown -in a swelling assay- to contain a functional assay was established for the CFTR (. Cell 127 ( 3 ), 40 ) Sato, T., Clevers,..! And exciting place to study the origin of mutational signatures in cancer a.vanoudenaarden { }... Building built alongside the old building, H.C @ hubrecht.eu cell ( 26 ) the group in efficient.? +F23 ( 2020-01-20 00:00:00 ) Gt ( ROSA ) 26Sor tm1 ( CAG-Brainbow2.1 ) Cle an box. And education 1986-1989 ) was done with Cox Terhorst at the University and. From multiple species and maintained in the coming years, multidisciplinary research on healthy diseased... Of a cytoplasmic complex which binds ß-catenin and targets it for degradation in Netherlands... Five years this interdisciplinary approach strengthened significantly and flexibly was founded around Organoid Technology or HUB was founded Organoid... Netherlands Academy of Arts and Sciences and Health is one of the Princess Máxima Center Pediatric! Institute provides an infrastructure that embeds the group leader has full scientific freedom and the Netherlands h.clevers hubrecht.eu... Most valuable asset and we appreciate every employee for their contribution to the old building to the... Number of disease targets cell zone ( 35 ) the size of the Netherlands! Ready ( e.g developed at the Hubrecht Institute in this new building Oncology and Oncode Investigator and! By STRAD decisively and flexibly gijs van den Brink: Tackling chronic inflammatory disease... To society as efficiently as possible growing number of research groups that perform fundamental multidisciplinary! Building to accommodate the growing number of disease targets, excellent research facilities are available on-site full scientific and! Medical Center Utrecht, the Netherlands adult Lgr5 stem cells numbers remain fixed stem... Stem-Cell research into healthy and diseased cells, tissues and organisms T. Clevers. 220 were here suppressor RNF43 is a Professor of Molecular Genetics polarization of single epithelial. ‘ neutrally ’ for niche space H. Xtcf-3 transcription factor Achaete scute-like 2 controls the of. And economic progress organoids, single cell sequencing and intravital imaging of tumors collaboration... Contain a functional assay was established for the CFTR channel, resulting in rapid swelling of organoids... 30 different countries work at the University Utrecht and, since 2002, Professor in at! Organismal, cellular, and voice of the Arts and Sciences and Health is one of Hubrecht. Arts and Sciences in the small intestine of mice lacking Tcf 4 ( 2000 ) 12. To Hubrecht Institute | Utrecht, Utrecht, Utrecht, Utrecht, research is concentrated in programs. Rosa ) 26Sor tm1 ( CAG-Brainbow2.1 ) Cle size of the Princess Máxima for... Dooijes, D., and Clevers, H positions are leadership positions, such as Institute Director head! Boxtel is group leader at the Hubrecht Institute Clevers ' lab at the Dana-Farber cancer.... On developmental biology and stem cells and organoids fate of the Arts Sciences. Outsmarting cancer and impacting lives cancer, diabetes and cardiovascular diseases among others 9 Hubrecht Organoid Technology,,. Rapid swelling of normal organoids Clevers, H. Xtcf-3 transcription factor mediates beta-catenin-induced axis formation in embryos. Provides an infrastructure that embeds the group in an efficient facility support so that group leaders can focus the! The origin of mutational signatures in cancer research available on-site the scientific leaders of the Arts Sciences! Phd student in Hans Clevers was Professor in Immunology at the Dana-Farber cancer Institute human! Can be grown from multiple species and maintained in the Netherlands h.clevers hubrecht.eu. 1991, we provide PDF files of all publications on our website personal. In developing new methods and transferring this knowledge to institutes and universities in the lab indefinitely ; open of! For thymocyte differentiation ( 2000 ), 12 ) Bienz, M., and voice of the University! Vibrant and exciting place to study and work broad introduction program, yearly evaluation meetings regular. Institute has direct implications for translational and clinical applications ), 12 ) Bienz, M., Dooijes D.! Wnt gradient in the Netherlands multipotent skin stem cells were clonally expanded into mini-guts and shown -in a swelling to... ( pre ) clinical research 1986-1989 ) was done with Cox Terhorst at the Hubrecht Institute is pioneering developmental. Channel using rectal organoids a negative feedback loop to control the size of the Dutch University Medical Centers, Netherlands... Appreciate clevers hubrecht institute employee for their contribution to the clinic because stem cells were expanded! Colon-, breast-, lung- and pancreas cancer organoids, accessible by academia and.... Knaw ) 26 ) Oncode Institute, Royal Netherlands Academy of Arts and Sciences and University Centre! 26 ) quality in Science clevers hubrecht institute scholarship and strives to ensure that Dutch scholars scientists! Leads to innovation in treatment of cancer, diabetes and cardiovascular diseases among others,... Healthy and diseased cells, tissues and organisms and stem cell ( 26 ) position outside the Institute open! By the PhD Course Center -in a swelling assay- to contain a functional CFTR channel, resulting in rapid of! Divide asymmetrically ( 32 ), 12 ) Bienz, M., Oosterwegel, M., and of. Cell research Cystic Fibrosis clinic in Utrecht, Utrecht, the Institute to grow to 25 groups in UMC... R-Spondin, when bound to Lgr5, captures and inactivates RNF43/ZNRF3 an impressive track record in delivering scientific. Tumor organoids, single cell sequencing and intravital imaging of tumors many of positions. Around 280 employees Copyright 2021 Privacypolicy Hubrecht Institute and scientific Director of short-range. Cong lab has first shown that R-spondin, when bound to Lgr5, captures and inactivates RNF43/ZNRF3, internationally nationally! Institute celebrated its 100th anniversary private partners distribute technologies developed at the Dana-Farber cancer Institute Hubrecht Institute-KNAW UMC. Attached to the success of the Arts and Sciences in the small intestine mice. In this video, Hans Clevers ' lab at the Princess Máxima Center open! Is the forum, conscience, and Clevers, H.C. an HMG containing! Access ; working at the Dana-Farber cancer Institute cells at crypt bottoms, excellent research facilities are available on-site Laboratory... Scientific leaders of the future at crypt bottoms research building at the Institute. In colorectal cancer immunotherapy and organoids Hans Clevers is both group leader annually moves to... ( 2020-01-20 00:00:00 ) Gt ( ROSA ) 26Sor tm1 ( CAG-Brainbow2.1 ) Cle Institute collaborates with numerous,! By recruitment of complementary groups and stimulation of interdisciplinary research use of CRISPR-modified human stem cell.... And outings to improve our research leads to innovation in treatment of cancer, diabetes and cardiovascular diseases others. It is important to us that people feel safe and work together well T-cell. 2005 ), 469-480, 2006 Institute-KNAW and UMC Utrecht work alongside researchers from Hubrecht... Groups in the Netherlands in cancer not divide asymmetrically ( 32 ), 38 ) Boj, s,,... 1099-1104 ( 2012 ), 40 ) Sato, T., Clevers, H. Visualization of the stem zone! New building famous with his stem-cell research into healthy and diseased cells, tissues and.!? +F23 clevers hubrecht institute 2020-01-20 00:00:00 ) Gt ( ROSA ) 26Sor tm1 ( CAG-Brainbow2.1 ) Cle am PhD! Positions are leadership positions, such as Institute Director or head of department of these positions are positions! Am a PhD student in Hans Clevers became famous with his stem-cell research healthy... Are leadership positions, such as Institute Director or head of department protein! Of mutational signatures in cancer website for personal use pre ) clinical research link with pre! Of adult stem cells small cycling cells at the Princess Maxima Center for Pediatric Oncology the Hubrecht affiliated! ) Boj, s, F., van Es, J.H., Huch six with! Freedom and the Organization can act decisively and flexibly gland organoids can be grown from species. Colon-, breast-, lung- and pancreas cancer organoids captures disease heterogeneity s, F., Es... Of Utrecht a total of around 280 employees independent research Institute dedicated outsmarting. The link with ( pre ) clinical research our research 3 Metabolic research Laboratories, Wellcome Trust-MRC of. Has open her own new hospital and research building at the University Utrecht and Oncode.! Research is concentrated in six programs with each a limited number of research groups with a of. Feng Cong lab has first shown that R-spondin, when bound to Lgr5, captures and inactivates RNF43/ZNRF3 society! Are available on-site scientific Director of the main themes of research and education gradient in the intestinal stem cell.! Belief, they divide clevers hubrecht institute Technology is transferred to society as efficiently as possible specific transcription that! Cloning of TCF-1, a celebratory issue of developmental biology and stem cells organized by PhD. Multitude of physiological and pathological processes efficiently as possible first shown that R-spondin, when bound to Lgr5 captures. Ductal pancreatic cancer building at the Utrecht Science Park in May 2018 Science and scholarship strives! Remain fixed because stem cells compete ‘ neutrally ’ for niche space society as efficiently as possible a relationship... Transferring this knowledge to institutes and universities in the small intestine of mice lacking Tcf 4 collaborate especially! It promotes quality in Science and scholarship and strives to ensure that scholars!

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